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Acute myeloid leukemia following solid organ transplantation: entity or novelty?
Author(s) -
Rashidi Armin,
Fisher Stephen I.
Publication year - 2014
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12288
Subject(s) - medicine , asymptomatic , myeloid leukemia , immunosuppression , transplantation , disease , leukemia , gastroenterology , incidence (geometry) , optics , physics
Due to the rarity of the disease, the characteristics of acute myeloid leukemia following solid organ transplantation (post‐transplant AML ; PT ‐ AML ) are unclear; furthermore, it is not known for certain whether PT ‐ AML is a separate entity or not. We provide a systematic review of all previously reported cases of PT ‐ AML in the English literature ( n = 51). 45% of cases occurred after renal transplantation, and 72% were males. The median age at diagnosis of AML was 50 yr, with a median transplant‐to‐ AML interval of 3.8 yr and a rapid decline in incidence after 5 yr. 26% of patients were asymptomatic at the time of presentation, and 42% were pancytopenic. M 0/ M 1/ M 2, M 3, M 4/ M 5, and M 6/ M 7 subtypes comprised 17%, 25%, 39%, and 19% of all cases, respectively. 36% of patients had unfavorable cytogenetic risk disease. The median overall survival was only 3 months. We observed several transplant‐specific features: (i) The transplant‐to‐ AML interval follows two very different patterns between renal vs. liver transplant patients. (ii) All 4 cases of donor cell leukemia occurred after liver transplant. (iii) Unfavorable risk disease was marginally significantly more common among renal compared with liver transplant patients ( P = 0.057). Our results suggest that PT ‐ AML is a separate entity with distinct characteristics, which need to be investigated further in future research. Heavy post‐transplant immunosuppression likely plays a key role in the pathogenesis of PT ‐ AML .