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Rapid remineralization of multiple disseminated bone lesions after high‐dose cytarabine in a patient with isolated myeloid sarcoma
Author(s) -
Brähler Sebastian,
Thielen Indra,
Schwabe Hendrik,
Engels Marianne,
Kreuzer KarlAnton,
Wolf Jürgen,
Ansén Sascha
Publication year - 2014
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12254
Subject(s) - cytarabine , myeloid sarcoma , medicine , myeloid leukemia , sarcoma , myeloid , chemotherapy , regimen , radiation therapy , oncology , induction chemotherapy , surgery , pathology
Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64‐yr‐old male patient. Remarkably, treatment with a high‐dose cytarabine regimen led to rapid remineralization of all bone lesions and recovery of the patient's mobility within a few weeks. Thereby, surgical treatment and radiotherapy could be avoided, supporting the role of intensive induction and standard consolidation chemotherapy as first‐line treatment for myeloid sarcoma.