Progressive Multifocal Leukoencephalopathy: a rare infectious complication following allogeneic hematopoietic cell transplantation ( HCT ) | Zendy

Kaufman Gregory P. | Zendy; Aksamit Allen J. | Zendy; Klein Christopher J. | Zendy; Yi Eunhee S. | Zendy; DeLone David R. | Zendy; Litzow Mark R. | Zendy

Premium

Progressive Multifocal Leukoencephalopathy: a rare infectious complication following allogeneic hematopoietic cell transplantation ( HCT )

Author(s) -

Kaufman Gregory P.,

Aksamit Allen J.,

Klein Christopher J.,

Yi Eunhee S.,

DeLone David R.,

Litzow Mark R.

Publication year - 2014

Publication title -

european journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 84

eISSN - 1600-0609

pISSN - 0902-4441

DOI - 10.1111/ejh.12208

Subject(s) - progressive multifocal leukoencephalopathy , medicine , jc virus , rituximab , hematopoietic stem cell transplantation , leukoencephalopathy , complication , transplantation , immunosuppression , demyelinating disorder , population , immunology , pathology , lymphoma , virus , multiple sclerosis , disease , environmental health

Progressive multifocal leukoencephalopathy ( PML ), a demyelinating disorder caused by brain infection with JC virus, is a neurological complication of immunocompromised states and immunosuppressive therapies. While most commonly seen in the HIV / AIDS population, patients with hematologic malignancies are also at risk following treatment protocols including monoclonal antibodies such as rituximab and after hematopoietic stem cell transplantation. Here, we present the case of PML following allogeneic HCT that highlights potential diagnostic difficulties. We also review the literature regarding PML following HCT and described therapies employed to attempt to treat this disorder.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research