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DNA interstrand cross‐link repair: understanding role of F anconi anemia pathway and therapeutic implications
Author(s) -
Shukla Pallavi,
Solanki Avani,
Ghosh Kanjaksha,
Vundinti Babu Rao
Publication year - 2013
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12169
Subject(s) - fanconi anemia , dna damage , dna , genotoxicity , dna repair , anemia , cancer research , chemistry , biology , medicine , genetics , toxicity
Interstrand cross‐links ( ICL s) are extremely toxic DNA lesions that prevent DNA double‐helix separation due to the irreversible covalent linkage binding of some agents on DNA strands. Agents that induce these ICL s are thus widely used as chemotherapeutic drugs but may also lead to tumor growth. Fanconi anemia ( FA ) is a rare genetic disorder that leads to ICL sensitivity. This review provides update on current understanding of the role of FA proteins in repairing ICL s at various stages of cell cycle. We also discuss link between DNA cross‐link genotoxicity caused by aldehydes in FA pathway. Besides this, we summarize various ICL agents that act as drugs to treat different types of tumors and highlight strategies for modulating ICL sensitivity for therapeutic interventions that may be helpful in controlling cancer and life‐threatening disease, FA .