Premium
Natural killer expansion, human leukocyte antigens‐ E expression and CD 14 + CD 56 + monocytes in a myelodysplastic syndrome patient
Author(s) -
Terrazzano Giuseppe,
Rubino Valentina,
Palatucci Anna Teresa,
Giovazzino Angela,
Annunziatella Mariangela,
Vitagliano Orsola,
Alfinito Fiorella,
Ruggiero Giuseppina
Publication year - 2013
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12152
Subject(s) - bone marrow , immunology , myelodysplastic syndromes , haematopoiesis , antigen , immune system , monocyte , stem cell , biology , chemistry , microbiology and biotechnology
Myelodysplastic syndromes ( MDS ) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune‐mediated mechanisms was evidenced as relevant for pathophysiology of MDS . Here, we described one case of MDS patient carrying CD 14 + CD 56 + monocytes in bone marrow ( BM ), in the presence of a defective human leukocyte antigen ( HLA )‐ E expression on peripheral blood ( PB ) cells and of natural killer ( NK ) cell expansion in PB and BM . The defective HLA ‐ E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD 14 + CD 56 + monocytes in BM .