Natural killer expansion, human leukocyte antigens‐ E  expression and  CD 14 +   CD 56 +  monocytes in a myelodysplastic syndrome patient | Zendy

Terrazzano Giuseppe | Zendy; Rubino Valentina | Zendy; Palatucci Anna Teresa | Zendy; Giovazzino Angela | Zendy; Annunziatella Mariangela | Zendy; Vitagliano Orsola | Zendy; Alfinito Fiorella | Zendy; Ruggiero Giuseppina | Zendy

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Natural killer expansion, human leukocyte antigens‐ E expression and CD 14 + CD 56 + monocytes in a myelodysplastic syndrome patient

Author(s) -

Terrazzano Giuseppe,

Rubino Valentina,

Palatucci Anna Teresa,

Giovazzino Angela,

Annunziatella Mariangela,

Vitagliano Orsola,

Alfinito Fiorella,

Ruggiero Giuseppina

Publication year - 2013

Publication title -

european journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 84

eISSN - 1600-0609

pISSN - 0902-4441

DOI - 10.1111/ejh.12152

Subject(s) - bone marrow , immunology , myelodysplastic syndromes , haematopoiesis , antigen , immune system , monocyte , stem cell , biology , chemistry , microbiology and biotechnology

Myelodysplastic syndromes ( MDS ) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune‐mediated mechanisms was evidenced as relevant for pathophysiology of MDS . Here, we described one case of MDS patient carrying CD 14 + CD 56 + monocytes in bone marrow ( BM ), in the presence of a defective human leukocyte antigen ( HLA )‐ E expression on peripheral blood ( PB ) cells and of natural killer ( NK ) cell expansion in PB and BM . The defective HLA ‐ E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD 14 + CD 56 + monocytes in BM .

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