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BAALC and WT1 expressions from diagnosis to hematopoietic stem cell transplantation: consecutive monitoring in adult patients with core‐binding‐factor‐positive AML
Author(s) -
Yoon JaeHo,
Kim HeeJe,
Shin SeungHwan,
Yahng SeungAh,
Lee SungEun,
Cho ByungSik,
Eom KiSeong,
Kim YooJin,
Lee Seok,
Min ChangKi,
Cho SeokGoo,
Kim DongWook,
Lee JongWook,
Min WooSung,
Park ChongWon,
Lim JiHyang
Publication year - 2013
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12142
Subject(s) - hematopoietic stem cell transplantation , stem cell , haematopoiesis , transplantation , medicine , immunology , biology , microbiology and biotechnology
No consecutive analysis of BAALC and WT 1 expressions associated with core‐binding factor AML ( CBF ‐ AML ) from diagnosis to hematopoietic stem cell transplantation ( HSCT ) has yet been reported. We investigated BAALC and WT 1 expressions using a method of real‐time quantitative polymerase chain reaction ( RQ ‐ PCR ) at diagnosis, after induction chemotherapy, at pre‐ HSCT , and at post‐ HSCT period in 45 consecutive patients [t(8,21) ( n = 28), inv(16) (n = 17)], who received HSCT as a post‐remission treatment. BAALC and WT 1 RQ ‐ PCR decrement ratio ( DR ) was also calculated at post‐induction chemotherapy, at pre‐ HSCT , and at post‐ HSCT compared with the diagnostic level. Higher BAALC expression at diagnosis showed significantly inferior OS ( P = 0.031), EFS ( P = 0.011), and higher CIR ( P = 0.002) rates. At post‐ HSCT , both higher BAALC and WT 1 expressions showed significantly inferior OS ( P = 0.005, 0.016), EFS ( P = 0.002, 0.006), and higher CIR ( P = 0.001, 0.003) rates. A subgroup of t(8;21) showing higher BAALC and WT 1 expressions at post‐ HSCT were also associated with inferior OS ( P = 0.018, 0.015) and higher CIR rates ( P = 0.019, 0.011). While BAALC DR showed no significant results on outcomes, WT 1 DR more than 2‐log at post‐ HSCT showed significantly lower CIR rate ( P = 0.028). This study showed that higher post‐ HSCT BAALC and WT 1 expressions in patients with CBF ‐ AML may be good markers of minimal residual disease for the prediction of survival and relapse after HSCT .