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Differences in the distribution of cytogenetic subtypes between multiple myeloma patients with and without a family history of monoclonal gammopathy and multiple myeloma
Author(s) -
Greenberg Alexandra J.,
Cousin Margot,
Kumar Shaji,
Ketterling Rhett P.,
Knudson Ryan A.,
Larson Dirk,
Colby Colin,
Scott Christopher,
Vachon Celine M.,
Vincent Rajkumar S.
Publication year - 2013
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12133
Subject(s) - multiple myeloma , monoclonal gammopathy , medicine , monoclonal gammopathy of undetermined significance , family history , distribution (mathematics) , pathology , monoclonal , immunology , monoclonal antibody , antibody , mathematics , mathematical analysis
We previously reported an increased risk of monoclonal gammopathy of undetermined significance ( MGUS ) in first‐degree relatives of MGUS and multiple myeloma patients. Here, we examine whether primary cytogenetic categories of myeloma differ between patients with and without a family history of MGUS or myeloma. We studied 201 myeloma patients with available data on family history and molecular cytogenetic classification. Myeloma with trisomies was more common in probands who had an affected first‐degree relative with MGUS or myeloma compared with those without a family history (46.9% vs. 33.5%, P = 0.125); however, the difference was not statistically significant. Additional studies on the cytogenetic types of myeloma associated with familial tendency are needed.