Premium
Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis
Author(s) -
Kucukgoncu Suat,
Kosir Urska,
Zhou Elton,
Sullivan Erin,
Srihari Vinod H.,
Tek Cenk
Publication year - 2019
Publication title -
early intervention in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.087
H-Index - 45
eISSN - 1751-7893
pISSN - 1751-7885
DOI - 10.1111/eip.12749
Subject(s) - insulin resistance , psychosis , mood , mood disorders , psychiatry , medicine , carbohydrate metabolism , diabetes mellitus , meta analysis , type 2 diabetes , glucose metabolism disorder , insulin , mental illness , endocrinology , psychology , mental health , anxiety
Aim To compare the differences of glucose metabolism outcomes between treatment‐naïve, patients with first episode psychosis (FEP) and mood disorders. Methods We conducted a systematic review and meta‐analysis of glucose intolerance in treatment‐naïve, first episode patients with severe mental illnesses (SMIs). Results We identified 31 eligible studies. Compared to healthy controls, FEP group have higher insulin and insulin resistance levels, and both groups have higher glucose tolerance test results. No significant differences were found in glucose metabolism outcomes between FEP and mood disorder groups. Conclusions Our results highlight impaired glucose metabolism at the onset of SMIs, suggesting both patients with psychosis and mood disorders are high‐risk groups for diabetes development.