Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis | Zendy

Kucukgoncu Suat | Zendy; Kosir Urska | Zendy; Zhou Elton | Zendy; Sullivan Erin | Zendy; Srihari Vinod H. | Zendy; Tek Cenk | Zendy

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Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

Author(s) -

Kucukgoncu Suat,

Kosir Urska,

Zhou Elton,

Sullivan Erin,

Srihari Vinod H.,

Tek Cenk

Publication year - 2019

Publication title -

early intervention in psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.087

H-Index - 45

eISSN - 1751-7893

pISSN - 1751-7885

DOI - 10.1111/eip.12749

Subject(s) - psychosis , insulin resistance , mood , mood disorders , psychiatry , medicine , diabetes mellitus , meta analysis , carbohydrate metabolism , bipolar disorder , type 2 diabetes , schizophrenia (object oriented programming) , insulin , psychology , endocrinology , anxiety

Aim To compare the differences of glucose metabolism outcomes between treatment‐naïve, patients with first episode psychosis (FEP) and mood disorders. Methods We conducted a systematic review and meta‐analysis of glucose intolerance in treatment‐naïve, first episode patients with severe mental illnesses (SMIs). Results We identified 31 eligible studies. Compared to healthy controls, FEP group have higher insulin and insulin resistance levels, and both groups have higher glucose tolerance test results. No significant differences were found in glucose metabolism outcomes between FEP and mood disorder groups. Conclusions Our results highlight impaired glucose metabolism at the onset of SMIs, suggesting both patients with psychosis and mood disorders are high‐risk groups for diabetes development.

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