Premium
Updated meta‐analysis of CMYA5 rs3828611 and rs4704591 with schizophrenia in Asian populations
Author(s) -
Hoya Satoshi,
Watanabe Yuichiro,
Shibuya Masako,
Someya Toshiyuki
Publication year - 2018
Publication title -
early intervention in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.087
H-Index - 45
eISSN - 1751-7893
pISSN - 1751-7885
DOI - 10.1111/eip.12472
Subject(s) - schizophrenia (object oriented programming) , meta analysis , odds ratio , confidence interval , medicine , random effects model , psychiatry
Aim Two single‐nucleotide polymorphisms, rs3828611 and rs4704591, in the cardiomyopathy‐associated protein 5 ( CMYA5 ) gene have been extensively investigated for associations with schizophrenia in Asian populations, but with conflicting results. To assess the collective evidence across individual studies, we conducted an updated meta‐analysis. Methods We performed a random‐effect model meta‐analysis of the associations of rs3828611 and rs4704591 with schizophrenia using seven case–control samples from Asian populations (8074 patients and 8139 controls). Results The meta‐analysis indicated that rs3828611 and rs4704591 were not significantly associated with schizophrenia (odds ratios [OR] = 0.93, 95% confidence interval [CI] = 0.85–1.01 and OR = 0.99, 95% CI = 0.93–1.05, respectively). Conclusions Our meta‐analysis did not provide evidence supporting a contribution of CMYA5 rs3828611 and rs4704591 to schizophrenia susceptibility in Asian populations.