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Various neurocognitive deficits and conversion risk in individuals at clinical high risk for psychosis
Author(s) -
Mourik Kees,
Decrescenzo Paula,
Brucato Gary,
Gill Kelly E.,
Arndt Leigh,
Kimhy David,
Keilp John G.,
Girgis Ragy R.
Publication year - 2017
Publication title -
early intervention in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.087
H-Index - 45
eISSN - 1751-7893
pISSN - 1751-7885
DOI - 10.1111/eip.12296
Subject(s) - neurocognitive , psychosis , psychology , schizophrenia (object oriented programming) , psychiatry , working memory , normative , clinical psychology , cognition , philosophy , epistemology
Aim Individuals at clinical high risk for psychosis ( CHR ) exhibit neurocognitive deficits in multiple domains. The aim of this study is to investigate whether several components of neurocognition are predictive of conversion to psychosis. Methods Fifty‐two CHR individuals were assessed with the S tructured Interview for P sychosis R isk S yndromes and completed a battery of neurocognitive tests at baseline including measures of executive functioning, attention, working memory, processing speed and reaction time. Neurocognitive functioning at baseline was scored based on an external normative control group. Most subjects were followed for 2.5 years to determine conversion status.Results Significant differences in neurocognitive functioning between CHR individuals and the control group were present in all domains. Twenty‐six per cent of the participants converted to psychosis within 9.8 (standard deviation = 8.0) months on average (median 9 months), but there were no significant differences in neurocognition converters and non‐converters. Conclusions Individuals at CHR have deficits in neurocognitive functioning, but such deficits do not appear to be related to conversion risk.