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Quality of life and functioning in first‐episode psychosis C hinese patients with different antipsychotic medications
Author(s) -
Lee Edwin H.M.,
Hui Christy L.M.,
Lin Jessie J.X.,
Ching Elaine Y.N.,
Chang W.C.,
Chan Sherry K.W.,
Chen Eric Y.H.
Publication year - 2016
Publication title -
early intervention in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.087
H-Index - 45
eISSN - 1751-7893
pISSN - 1751-7885
DOI - 10.1111/eip.12246
Subject(s) - amisulpride , olanzapine , risperidone , antipsychotic , psychiatry , psychosis , psychology , brief psychiatric rating scale , global assessment of functioning , ziprasidone , quality of life (healthcare) , schizophrenia (object oriented programming) , rating scale , akathisia , medicine , clinical psychology , developmental psychology , psychotherapist
Aim This study compared the quality of life and functioning of 285 first‐episode psychosis C hinese patients with different antipsychotic medications in H ong K ong. Method Under the J ockey C lub E arly P sychosis project, a total of 285 patients were recruited from all inpatient and outpatient psychiatric units in H ong K ong between 2009 and 2011. In addition to the medication information, patients were assessed with the S cale for the A ssessment of P ositive S ymptoms, the S cale for the A ssessment of N egative S ymptoms, the U dvalg for K liniske U ndersøgelser ( UKU ), B arnes A kathisia R ating S cale ( BARS ), the S ocial and O ccupational F unctioning A ssessment S cale ( SOFAS ), the R ole F unctioning S cale, and the M edical O utcomes S tudy S hort F orm 12‐ I tem H ealth S urvey ( SF ‐12) after stabilization of mental condition. Differences between individual antipsychotic medications were compared using anova and multinomial regression model. Results The results demonstrated significant differences between different antipsychotic medications in the mean of UKU neurological subscore, BARS total score, SOFAS score and SF ‐12 Mental Component Summary ( MCS ) score. Patients with haloperidol had higher mean UKU neurological subscore than patients with olanzapine or amisulpride. Risperidone was associated with higher mean BARS total score than olanzapine, amisulpride or sulpiride. Higher mean MCS was found in patients with amisulpride than patients with risperidone. Conclusions The findings suggest that antipsychotics have differential associations with the quality of life and functioning in patients with first‐episode psychosis. Future prospective study is warranted to investigate if patients with first‐episode psychosis will benefit specific type of antipsychotics more than the others.