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Relationship between menarche and psychosis onset in women with first episode of psychosis
Author(s) -
RubioAbadal Elena,
Usall Judith,
Barajas Anna,
Carlson Janina,
Iniesta Raquel,
HuertaRamos Elena,
Baños Iris,
Dolz Montserrat,
Sánchez Bernardo,
Ochoa Susana
Publication year - 2016
Publication title -
early intervention in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.087
H-Index - 45
eISSN - 1751-7893
pISSN - 1751-7885
DOI - 10.1111/eip.12194
Subject(s) - psychosis , menarche , psychology , psychiatry , population , age of onset , medicine , pediatrics , clinical psychology , environmental health , disease
Aim The aim of this study was to explore the relationship between age at menarche and age at first episode of psychosis, as well as clinical severity and outcome, in a population of women with first‐episode psychosis. Methods Clinical and socio‐demographical data, age at menarche and at first‐episode psychosis, parental history of psychosis and cannabis‐use habits were obtained from 42 subjects with a first episode of psychosis. P ositive and N egative S yndrome S cale, C linical G lobal I mpression, Global Assessment Function, D isability A ssessment S chedule, W echsler A dult I ntelligence S cale and W echsler I ntelligence S cale for C hildren, E uropean Q uality of L ife, and L ewis and M urray O bstetric C omplication Scales were administered. Statistical analysis was performed by means of zero‐order correlations and M ann– W hitney U and K ruskal– W allis tests using SPSS version 17.0. Results We found no significant correlation between age at menarche and age at first‐episode psychosis, or with the clinical scores performed. We observed that subjects with earlier age at menarche had more parental history of psychosis. Conclusions Our negative results do not support the theory of a possible protective role of oestrogen, which seems to be more complex than previously thought. We would suggest that further research is needed to investigate developmental influences of sex steroids on the onset of psychosis and potentially therapeutic benefits based upon oestrogen.