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The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs
Author(s) -
Kwon Youngil,
Ko Hyunjung,
Kim Soojung,
Kim Miri
Publication year - 2018
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/edt.12397
Subject(s) - replantation , tooth replantation , medicine , resorption , dentistry , root canal , beagle , in vivo , root resorption , cathepsin k , surgery , osteoclast , biology , receptor , microbiology and biotechnology
Background/Aim Continuous research efforts have been focusing on promoting healing of delayed replantation of avulsed teeth. The aim of this in vivo study was to assess the effect of cathepsin K inhibitor surface treatment on delayed tooth replantation. Materials and Methods Thirty‐four premolar roots of 4 beagle dogs were extracted, and conventional root canal treatment was performed. The canals were filled with gutta‐percha and cement. All extracted teeth were air‐dried for 1 hour. Teeth were divided into 2 groups according to the root surface treatment prior to replantation: control (n = 13) and cathepsin K inhibitor (n = 21). Treated teeth were replanted in their original sockets and stabilized with a resin‐wire splint for 1 week. After 12 weeks, the dogs were euthanized and micro‐computed tomography was performed. Tissues were then further processed as resin‐embedded specimens stained with hematoxylin and eosin. In each evaluation, data were analyzed using the Mann‐Whitney U test ( P < .05). Results In the micro‐computed tomography evaluation, inflammation scores of both groups were not statistically different ( P > .05). In the histological evaluation, the mean proportions of inflammatory resorption and replacement resorption in the control group were similar to those in the cathepsin K inhibitor group ( P > .05). Conclusions Cathepsin K inhibitor did not demonstrate significant inhibitory effects on root resorption after delayed replantation in vivo.