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Effect of bisphosphonates on root resorption after tooth replantation – a systematic review
Author(s) -
Najeeb Shariq,
Siddiqui Fahad,
Khurshid Zohaib,
Zohaib Sana,
Zafar Muhammad Sohail,
Ansari Shazia Akbar
Publication year - 2017
Publication title -
dental traumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 81
eISSN - 1600-9657
pISSN - 1600-4469
DOI - 10.1111/edt.12316
Subject(s) - medicine , dentistry , resorption , root resorption , replantation , tooth avulsion , tooth replantation , bone resorption , bisphosphonate , animal studies , osteoporosis , orthodontics , surgery , incisor
Abstract Background/Aim Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an antiresorptive effect on periodontal bone as well. The antiresorptive properties of BPs could prove them useful in preventing root resorption of replanted avulsed teeth. The aim of this systematic review was to analyze and summarize the currently available literature concerning the use of BPs in preventing root resorption of avulsed teeth. Materials and methods PubMed/MEDLINE, Google Scholar, ISI Web of Knowledge, and Embase databases were searched using keywords ‘bisphosphonate’, ‘replantation’, and ‘tooth’. Quality assessment of each study was carried out. In addition, general characteristics and outcomes of each study were summarized. Results After exclusion of 116 irrelevant articles, 10 animal studies were included in this review. The majority of the studies suggest that surface application of zoledronate or alendronate reduces root resorption of replanted teeth in animal models. Surface treatment with etidronate had no significant effect on root resorption, and intracanal etidronate accelerated resorption. Conclusion Surface application of zoledronate and alendronate reduces root resorption of replanted teeth in animal models. However, the efficacy of intracanal usage of BPs is still debatable.