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Pathogenesis of Redistribution of Intrarenal Blood Flow in Haemorrhagic Hypotension* **
Author(s) -
Grandchamp A.,
Ayer G.,
Trunniger B.
Publication year - 1971
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.1971.1.4.271
Subject(s) - phenoxybenzamine , renal blood flow , phentolamine , medicine , papaverine , perfusion , blood flow , anesthesia , hemodynamics , propranolol
Haemorrhagic hypotension (HH) has been shown to cause a progressive and patchy hypoperfusion of the renal cortex. In order to evaluate the mechanisms responsible for this redistribution of renal blood flow (RBF) the effect of acetylcholine, papaverine, and alpha‐adrenergic blockade (phenoxybenzamine or phentolamine) upon the patchy cortical hypoperfusion was studied in 19 anaesthetised dogs. By means of the 133 Xenon washout technique and 85 Krypton autoradiographies the intrarenal distribution of blood flow (IDBF) and local blood flow rates (F 1 ) were determined with normal blood pressure and during HH, before and during the infusion of the above compounds into the renal artery. While papaverine and acetylcholine did not modify the patchy cortical hypoperfusion, α‐adrenergic blockade completely prevented or corrected the redistribution of RBF in HtbAutoradiography under haemorrhagic hypotension with alpha blockade showed a homogeneous perfusion of the renal cortex. Infusion into the renal artery of phenoxybenzamine blocked the renal haemodynamic effects of norepinephrine but not those of angiotensin. From these observations it is concluded that sympathoadrenergic factors are mainly responsible for the redistribution of RBF seen in haemorrhagic hypotension.