Premium
Selenium status and oxidative stress in obese: Influence of adiposity
Author(s) -
Soares de Oliveira Ana R.,
Jayanne Clímaco Cruz Kyria,
Beatriz Silva Morais Jennifer,
Rocha Dos Santos Loanne,
Rodrigues de Sousa Melo Stéfany,
Fontenelle Larissa C.,
Santos de Sousa Gustavo,
Costa Maia Carla Soraya,
Oliveira Duarte de Araújo Camilla,
Leal Mendes Islanne,
Simeone Henriques Gilberto,
Costa Silva Vladimir,
Nascimento Marreiro Dilina
Publication year - 2021
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13538
Subject(s) - selenium , medicine , endocrinology , waist , glutathione peroxidase , body mass index , thiobarbituric acid , chemistry , oxidative stress , excretion , lipid peroxidation , catalase , organic chemistry
Background Selenium deficiency appears to limit antioxidant defense in obese individuals. This study evaluated the association between adiposity indices, selenium status, and oxidative stress in obese women. Methods This was a cross‐sectional study involving 139 women who were divided into the following two groups: the case group (obese women, n = 63) and the control group (normal‐weight women, n = 76). Plasma, erythrocyte, and urinary selenium levels were determined using inductively coupled plasma optical emission spectrometry. Body weight, height, waist circumference, hip circumference and neck circumference were measured. Body mass index, waist/height ratio, conicity index, body fat index, body adiposity index, body circularity index, and visceral adiposity index were calculated. Plasma levels of thiobarbituric acid reactive substances were determined. The erythrocyte glutathione peroxidase activity was determined using an automatic biochemical analyzer and Ransel kit. Results Obese women had selenium deficiency characterized by reduction in plasma and erythrocyte concentrations ( P < .001). The urinary selenium excretion was higher in the case group compared to the control group ( P < .001). Adiposity indices values and plasma concentrations of thiobarbituric acid reactive substances were significantly elevated in obese women ( P < .001). There was a significant association between adiposity indices and selenium status ( P < .001), and between erythrocyte selenium and erythrocyte glutathione peroxidase activity ( P < .001). Conclusion Obese women evaluated in the study have reduced plasma and erythrocyte concentrations of selenium and an increased urinary excretion of selenium. The correlation analysis reveals an association between intra‐abdominal fat accumulation and selenium metabolism and oxidative stress.