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Sperm, metabolic memory and echoes from Lamarck
Author(s) -
Crisóstomo Luís,
Oliveira Pedro F.,
Alves Marco G.
Publication year - 2021
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13492
Subject(s) - offspring , epigenetics , spermatozoon , zygote , biology , in utero , sperm , gamete , affect (linguistics) , genetics , pregnancy , embryo , psychology , embryogenesis , fetus , gene , communication
There is a widespread misconception that only maternal variables affect in utero development. Epigenetic markers carried by the spermatozoon are transmitted to the zygote. Sperm‐born epigenetic factors influence in utero development, for various generations. Acquired traits of metabolic disease can be inherited by the offspring via the male gamete. Health assessment of future fathers is essential to predict the offspring's health.