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Toothbrushing frequency and gastric and upper aerodigestive tract cancer risk: A meta‐analysis
Author(s) -
Wu Huadong,
Zhang Jinjia,
Zhou Baojun
Publication year - 2021
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13478
Subject(s) - medicine , meta analysis , cancer , cochrane library , relative risk , risk factor , epidemiology , oncology , gastroenterology , confidence interval
Objective Results of epidemiological studies evaluating the association between toothbrushing and gastric and upper aerodigestive tract (UADT) cancer risk showed inconsistent results. The purpose of this study was to evaluate the association between toothbrushing and gastric and UADT cancer risk and quantify the dose‐response association between them. Methods We searched the PubMed, EMBASE and Cochrane Library databases to identify relevant studies on toothbrushing and gastric and UADT cancer risk. Statistical analyses were performed using STATA 12.0 software. Results A total of 30 studies of involving 1 194 017 participants met eligibility criteria and were included in the meta‐analysis. Meta‐analysis using a random‐effect model showed that the high frequency of toothbrushing was associated with significantly reduced risk of gastric and UADT cancers (OR: 0.55, 95% CI 0.46‐0.64, P < .05). Our dose‐response analysis presented that every increased toothbrushing per day might reduce oral cavity cancer risk by 6%, pharyngeal cancer risk by 11%, laryngeal cancer risk by 3%, oesophageal cancer risk by 6% and gastric cancer risk by 4%. Conclusions This meta‐analysis suggested the negative relationship between frequency of toothbrushing and risk of gastric and UADT cancers. Toothbrushing may be a protective factor for gastric and UADT cancers. However, this association must be further validated through large prospective studies.