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Effects of exercise programmes on pain, disease activity and function in ankylosing spondylitis: A meta‐analysis of randomized controlled trials
Author(s) -
Hu Xinmiao,
Chen Jialing,
Tang Wenjuan,
Chen Wenjian,
Sang Yan,
Jia Lina
Publication year - 2020
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13352
Subject(s) - basfi , basdai , ankylosing spondylitis , medicine , physical therapy , randomized controlled trial , visual analogue scale , spondylitis , erythrocyte sedimentation rate , disease , psoriatic arthritis
Background To evaluate the effects of exercise programmes on pain, function and disease activity in patients with ankylosing spondylitis (AS). Materials and methods We searched PubMed, Embase, CNKI and Wanfang from inception to February 2020. Randomized controlled trials comparing exercises with nonexercise interventions in AS patients were applied. Studies that assessed the visual analogue scale (VAS) pain score, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), C‐reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were included. Outcomes of home‐based exercise intervention were also reported independently. Results Ten studies met the inclusion criteria in all, including 534 patients (278 exercise, 256 control). Compared with the nonexercise group, exercise group had statistically significant improvements in pain (weighted mean difference [WMD]: −1.02 [95% CI: −1.50 to −0.55]) ( I 2 : 31%, P <.0001), BASDAI (WMD: −0.85 [95% CI: −1.09 to −0.61]) ( I 2 : 20%, P <.00001), and BASFI (WMD: −0.66 [95% CI: −0.95 to −0.38]) ( I 2 : 0%, P <.00001), but not in CRP and ESR. What's more, home‐based exercise programmes had positive impacts on BASFI, BASDAI and pain. Conclusions For patients with AS, exercise programmes improve pain, function and disease activity. To confirm the results, more well‐designed randomized controlled trials with large number of patients are required.