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Association between diabetes mellitus and lung cancer: Meta‐analysis
Author(s) -
Yi ZiHan,
Luther Yannick,
Xiong GuoHang,
Ni YueLi,
Yun Fang,
Chen Jing,
Yang Zhe,
Zhang Qiao,
Kuang YingMin,
Zhu YueChun
Publication year - 2020
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13332
Subject(s) - medicine , lung cancer , subgroup analysis , relative risk , meta analysis , diabetes mellitus , cohort study , confounding , incidence (geometry) , cochrane library , cohort , publication bias , cancer , oncology , confidence interval , endocrinology , physics , optics
Background This study aimed to summarize the association between diabetes mellitus (DM) and the incidence of lung cancer using a meta‐analysis of cohort studies. Materials and methods We systematically searched PubMed, Embase and the Cochrane Library to identify potential cohort studies. Relative risk (RR) was used to calculate the association between DM and the risk of lung cancer. Subgroup analysis, sensitivity analysis and test for publication bias were performed. Twenty cohort studies were selected. Results The participants with DM showed little or no significant effect on the risk of lung cancer (RR: 1.10; 95% CI: 0.99‐1.23; P = .087). DM was not associated with the risk of lung cancer in men (RR: 1.11; 95%CI: 0.92‐1.35; P = .270), but a significant association was observed in women (RR: 1.18; 95%CI: 1.10‐1.28; P < .001). Subgroup analysis suggested that smoker status was confounding variables that could bias the relationship between DM and the incidence of lung cancer. Conclusions This meta‐analysis suggests that DM has no significant impact on the incidence of lung cancer in men but has a harmful effect on women.