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The association between CYBA gene C242T variant and risk of metabolic syndrome
Author(s) -
Pourgholi Leyla,
Pourgholi Fatemeh,
Ziaee Shayan,
Goodarzynejad Hamidreza,
Hosseindokht Maryam,
Boroumand Mohammadali,
Mandegary Ali
Publication year - 2020
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13275
Subject(s) - metabolic syndrome , medicine , confounding , odds ratio , endocrinology , allele , body mass index , population , restriction fragment length polymorphism , biology , genotype , genetics , obesity , gene , environmental health
Background Both inflammation and oxidative stress may contribute to pathogenesis of metabolic syndrome (MetS). The C242T polymorphism (rs4673) in the CYBA gene, as the main components of NAD (P) H oxidase, causes inter‐individual variability in the enzyme activity. We aimed to investigate the association between this polymorphism with MetS and its components. Methods Two hundred nine patients with MetS and 232 controls were included in this study. MetS was defined based on NCEP ATP‐III A criteria with some modifications. The C242T polymorphism within CYBA gene was determined by using PCR‐based restriction fragment length polymorphism (PCR‐RFLP) method. Results After applying a multiple logistic regression model with adjusting for potential confounders of MetS including, age, sex, body mass index, hypertension, used medications, and diabetes mellitus, C242T polymorphism was found to be associated with the presence of MetS in men but not in the total population or in women. T allele as compared to C allele was associated with decreased odds of MetS in men (adjusted OR = 0.42, 95% CI = 0.24‐0.74; P = .003), but not in women (adjusted OR = 1.03, 95% CI = 0.07‐1.61; P = .890), or in the total population (adjusted OR = 0.72, 95% CI = 0.51‐1.02; P = .063). Conclusion This study shows that T allele of C242T polymorphism in CYBA gene is protective against MetS in Iranian men but not in women. Further cohort studies with larger sample size in subgroups of men and women are required to confirm such association in other racial or ethnic group.