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Chemerin predicts carotid intima‐media thickening in severe obesity
Author(s) -
Ministrini Stefano,
Ricci Maria Anastasia,
Nulli Migliola Elisa,
De Vuono Stefano,
D’Abbondanza Marco,
Paganelli Maria Teresa,
Vaudo Gaetano,
Siepi Donatella,
Lupattelli Graziana
Publication year - 2020
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13256
Subject(s) - chemerin , medicine , insulin resistance , body mass index , endocrinology , adipokine , lipid profile , intima media thickness , waist , obesity , homeostatic model assessment , gastroenterology , diabetes mellitus , carotid arteries
Background and aims Chemerin is an adipokine with an emerging role in the crosstalk between adipose tissue and immune system. It is overexpressed in severe obesity, affects adipogenesis and glucose homeostasis and it correlates with early vascular damage. The aim of this study is to investigate the correlation between circulating levels of chemerin and early vascular damage in subjects with severe obesity, before and after laparoscopic sleeve gastrectomy (LSG). Methods Fifty‐six obese subjects eligible for LSG were enrolled in the study. The following parameters were evaluated: body mass index (BMI), glycemia, insulinemia, glycated haemoglobin, lipid profile, plasma chemerin levels and carotid intima‐media thickness (cIMT). Fifty‐four subjects were evaluated 1 year after the intervention. Results Univariate analysis showed a direct and significant correlation between chemerin and waist circumference, insulin resistance, glycated haemoglobin and cIMT. Chemerin was a better predictor of intima‐media thickening than waist circumference and glycated haemoglobin at the ROC curve analysis, with a cut‐off value for chemerin of 140 ng/mL. The reduction of chemerin is independently associated with the reduction of cIMT and the improvement of insulin sensitivity after LSG. Conclusion Chemerin is involved in the development and progression of early vascular damage and insulin resistance in subjects with severe obesity, and in their healing after bariatric surgery. Chemerin could also have a role in the assessment of cardiovascular risk in subjects with severe obesity.