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Neutrophil recruitment and intracellular vesicle transport: A short overview
Author(s) -
MasgrauAlsina Sergi,
Sperandio Markus,
Rohwedder Ina
Publication year - 2020
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13237
Subject(s) - rab , intracellular , microbiology and biotechnology , effector , vesicle , compartment (ship) , gtpase , small gtpase , biology , vesicular transport protein , signal transduction , biochemistry , membrane , oceanography , geology
Recruitment of neutrophils from the intravascular compartment into injured tissue is an essential component of the inflammatory response. It involves intracellular trafficking of vesicles within neutrophils and endothelial cells, both containing numerous proteins that have to be distributed in a tightly controlled and precise spatiotemporal fashion during the recruitment process. Rab proteins, a family of small GTPases, together with their effectors, are the key players in guiding and regulating the intracellular vesicle trafficking machinery during neutrophil recruitment. This review will provide a short overview on this process and highlight new findings as well as current controversies in the field.