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Pulse wave velocity to the global longitudinal strain ratio in survivors of myocardial infarction
Author(s) -
Wykretowicz Andrzej,
Schneider Agata,
Krauze Tomasz,
Szczepanik Adam,
Banaszak Agnieszka,
Minczykowski Andrzej,
Piskorski Jaroslaw,
Guzik Przemyslaw
Publication year - 2019
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13131
Subject(s) - cardiology , medicine , pulse wave velocity , myocardial infarction , arterial stiffness , hazard ratio , ejection fraction , clinical endpoint , confidence interval , blood pressure , heart failure , randomized controlled trial
Background New index of pulse wave velocity to global longitudinal peak systolic strain (PWV/GLPSS) was reported to be associated with cardiovascular damage. We evaluated the prognostic role of this metric in survivors of acute myocardial infarction (AMI). Material and methods We investigated in 569 patients with AMI, whether PWV/GLPSS was associated with a composite endpoint of death, stroke or new myocardial infarction, in long‐term follow‐up. Left ventricular longitudinal strain was evaluated by speckle tracking, and carotid arterial stiffness (local PWV) was determined using radiofrequency data technology. Results During follow‐up (median 1316 days), 114 subjects reached composite endpoint. These subjects were significantly older ( P < 0.0001) and were characterized by lower ejection fraction ( P < 0.0001), lower GLPSS ( P < 0.0001), higher PWV ( P = 0.007) and lower PWV/GLPSS index ( P < 0.0001). Patients with PWV/GLPSS <−0.74 were at a significantly higher risk for the composite endpoint during the follow‐up (hazard rate: 1.7; 95% confidence interval: 1.2‐2.6; P < 0.001). The PWV/GLPSS was additive to the predictive value of EF < 35%—patients with PWV/GLPSS <−0.74 and EF < 35% had the highest risk for the endpoint events. Conclusions The current study shows that PWV/GLPSS index has significant, independent and additive value in predicting CV complications, in subjects with myocardial infarction.