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Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis
Author(s) -
He Cuifang,
Lin Peihuan,
Liu Wenbing,
Fang Kuaifa
Publication year - 2019
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13074
Subject(s) - hyperuricemia , medicine , acute coronary syndrome , meta analysis , uric acid , confidence interval , relative risk , myocardial infarction
Background The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta‐analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS. Methods A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected. Outcome of interests was major adverse cardiovascular events (MACEs), all‐cause mortality or cardiovascular mortality. Results A total of nine studies enrolling 8776 ACS patients were included and analysed. ACS patients with hyperuricemia had an increased risk of MACEs (risk ratio [RR]: 1.86; 95% confidence intervals [CI]: 1.47‐2.35), all‐cause mortality (RR 1.86; 95% CI: 1.49‐2.32) and cardiovascular mortality (RR: 1.74; 95% CI: 1.36‐2.22) after adjustment for the conventional risk factors. Stratified analysis showed that the prognostic significance of hyperuricemia was consistently observed in each subgroups. Conclusions This meta‐analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients.