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Plasma sMer, sAxl and GAS6 levels correlate with disease activity and severity in lupus nephritis
Author(s) -
Gong Siwen,
Xu Zhaozhen,
Liu Yang,
Xing Li,
Ma Jing,
Yu Chengyuan,
Liu Xiaogang,
Jia Xibei,
Xie Rujuan,
Sui Manshu
Publication year - 2019
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13064
Subject(s) - lupus nephritis , nephritis , medicine , gas6 , renal function , receptor , endocrinology , gastroenterology , immunology , disease , receptor tyrosine kinase
Objective The purpose of this study is to determine whether TAM receptors and ligands associated with the activity and severity of lupus nephritis. Methods Clinical data were statistically analysed and studied in 122 SLE patients, diagnosed from 2013 to 2016 in First Hospital Affiliated to Harbin Medical University. Levels of TAM receptors and ligands in the plasma of 122 SLE patients were measured by ELISA . Renal biopsies were performed to confirm lupus nephritis ( LN ) by histopathology in 68 patients. The associations of TAM receptors and ligands with clinical and serological parameters were analysed in 68 LN patients. Results Amongst patients with SLE , those with LN had significantly higher plasma sM er, sA xl and GAS 6 levels than those without renal involvement ( P < 0.01 for all comparisons). Additional comparisons on the renal function‐associated clinical parameters confirmed an indicative role of the sM er, sAXL and GAS 6 levels in the cohort of patients with more severe nephritis. Patients with higher sM er, sAXL and GAS 6 levels of LN patients tended to suffer from proliferative glomerulonephritis. The sAXL and GAS 6 levels had a strong positive correlation with activity index ( AI ) in LN patients. Furthermore, there was a significant drop of the sM er, sAXL and GAS 6 concentrations from the time of the biopsy to month t6, but no further decrease from months t6 to t12. Conclusions These results suggest that plasma sM er, sA xl and GAS 6 can be an additional clinical marker related to the disease activity and severity in LN.