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SOX6 rs7117858 polymorphism is associated with osteoporosis and obesity‐related phenotypes
Author(s) -
CorreaRodríguez María,
SchmidtRioValle Jacqueline,
RuedaMedina Blanca
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13011
Subject(s) - body mass index , obesity , osteoporosis , confounding , medicine , population , demography , endocrinology , environmental health , sociology
Background SOX 6 has been recently proposed as a pleiotropic gene for obesity and osteoporosis. The aim of this study was to investigate whether the rs7117858 genetic variant in SOX 6 was associated with bone mass assessed by quantitative ultrasound ( QUS ) and obesity‐related measures in a population of young adults. Methods A cross‐sectional study was conducted in 550 unrelated healthy individuals of Caucasian ancestry (381 (69.3%) female and 169 (30.7%) male; mean age 20.46 ± 2.69). Bone mass was assessed through calcaneal QUS ) parameter ( BUA , dB / MH z). Obesity‐related traits including weight, body mass index ( BMI ), fat mass ( FM ) and fat‐free mass ( FFM ) were analysed. Results The linear regression analysis revealed that the rs7117858 SNP was significantly associated with FFM after adjustments for covariables in the whole sample ( P = 0.027, β (95% CI ) = 0.053 (0.092, 1.516). In addition, a significant association with QUS measurement adjusted for confounding factors was found in females ( P = 0.043, β (95% CI ) = 0.104 (0.138. 8.384). Conclusions We demonstrate for the first time that SOX 6 influence FFM and QUS trait in a population of young adults, suggesting the implication of this gene in obesity and osteoporosis‐related phenotypes during early adulthood.