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The underestimated role of basophils in Ph + chronic myeloid leukaemia
Author(s) -
Valent Peter,
Horny HansPeter,
Arock Michel
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.13000
Subject(s) - cancer research , immunology , stem cell , myeloid , haematopoiesis , autocrine signalling , progenitor cell , medicine , vascular endothelial growth factor , biology , microbiology and biotechnology , receptor , vegf receptors
Chronic myeloid leukaemia ( CML ) is a hematopoietic neoplasm defined by the chromosome translocation t(9;22) and the related oncogene, BCR ‐ ABL 1 . In most patients, leukaemic cells can be kept under control using BCR ‐ ABL 1‐targeting drugs. However, many patients relapse which remains a clinical challenge. In particular, patients with advanced (accelerated or blast phase) CML have a poor prognosis. So far, little is known about molecular and cellular interactions and features that contribute to disease progression and drug resistance in CML . One key prognostic factor at diagnosis is marked basophilia. However, although basophils are well‐known multifunctional effector cells, their impact in CML remains uncertain. In this article, we discuss the potential role of basophils as active contributors to disease evolution and progression in CML . In particular, basophils serve as a unique source of inflammatory, angiogenic and fibrogenic molecules, such as vascular endothelial growth factor or hepatocyte growth factor. In addition, basophils provide vasoactive substances, like histamine as well as the cytokine‐degrading enzyme dipeptidyl‐peptidase IV which may promote stem cell mobilization and the extramedullary spread of stem and progenitor cells. Finally, basophils may produce autocrine growth factors for myeloid cells. Understanding the role of basophils in CML evolution and progression may support the development of more effective treatment concepts.