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Neutrophils as myeloid‐derived suppressor cells
Author(s) -
Aarts Cathelijn E. M.,
Kuijpers Taco W.
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12989
Subject(s) - myeloid derived suppressor cell , immune system , immunology , myeloid , myelopoiesis , population , cell , biology , innate immune system , suppressor , microbiology and biotechnology , bone marrow , chemistry , cancer research , cancer , haematopoiesis , medicine , stem cell , genetics , environmental health
Neutrophils form the first line of defence against invading pathogens, such as bacteria and fungi, as part of the innate immune response. Recently, neutrophils have also been discovered as repressors of adaptive immune responses. Under certain conditions, such as cancer and severe injury, an expansion of immature and mature neutrophils has been observed to induce suppression of T‐cell proliferation. These suppressing cells are known as so‐called myeloid‐derived suppressor cells ( MDSC s), a heterogeneous population of granulocytic‐ MDSC s and monocytic‐ MDSC s. Initially, MDSC s were believed to be a specific immature type of myeloid immune cell released from the bone marrow, but mature neutrophils have also been proposed to have suppressive capacity. However, granulocytic‐ MDSC s show a similar morphology and expression of cell surface markers as mature neutrophils. The only characteristic that discriminates granulocytic (g)‐ MDSC s from mature neutrophils is their suppressive capacity, raising the question whether human g‐ MDSC s and neutrophils are actually different cell types or whether they are one plastic cell type that can functionally polarize from microbial killers to immunosuppressor cells, depending on local conditions. In this review, we will focus on the MDSC activity of circulating mature neutrophils.