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Calcium signalling and related ion channels in neutrophil recruitment and function
Author(s) -
Immler Roland,
Simon Scott I.,
Sperandio Markus
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12964
Subject(s) - microbiology and biotechnology , extracellular , calcium , intracellular , phagocytosis , calcium signaling , cytosol , chemistry , function (biology) , orai1 , calcium in biology , ion channel , receptor , biology , voltage dependent calcium channel , biochemistry , enzyme , organic chemistry
Abstract The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca 2+ store depletion and the influx of extracellular Ca 2+ via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca 2+ signalling is initiated in neutrophils and how changes in intracellular Ca 2+ levels modulate neutrophil function.