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CXCR 4, the master regulator of neutrophil trafficking in homeostasis and disease
Author(s) -
De Filippo Katia,
Rankin Sara M.
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12949
Subject(s) - chemokine , regulator , homeostasis , context (archaeology) , inflammation , immunology , bone marrow , biology , microbiology and biotechnology , medicine , gene , paleontology , biochemistry
Background Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. Results The CXCR 4/ CXCL 12 chemokine axis has been identified as a central regulator of these processes. Conclusion In this review, we focus on the role of CXCR 4/ CXCL 12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease. We also discuss the role of CXCR 4 in fine‐tuning neutrophil responses in the context of inflammation.