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Elevated high‐sensitive troponin T in negative stress test individuals
Author(s) -
Brzezinski Rafael Y.,
Fisher Eyal,
Ehrenwald Michal,
Shefer Gabi,
Stern Naftali,
Shapira Itzhak,
Zeltser David,
Berliner Shlomo,
ShenharTsarfaty Shani,
Milwidsky Assi,
Rogowski Ori
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12930
Subject(s) - troponin complex , medicine , troponin t , cohort , population , troponin , cardiology , myocardial infarction , environmental health
Background The exercise ECG stress test ( EST ) is still the first step of work‐up in intermediate risk patients in many clinical scenarios. High‐sensitive cardiac troponin T (hs‐ cTnT ) elevation is related to future cardiovascular events in the general population and in patients with ischaemic heart disease. The relation between these 2 tests is not well described. Materials and methods A total of 2780 participants from the Tel‐Aviv Medical Center Inflammation Survey cohort (mean age 49 years, 79% men) were analysed. Multiple physiologic and metabolic parameters including hs‐ cTnT were collected. All participants completed an EST manually reviewed by a cardiologist. Results A positive EST was documented in 224 subjects (8%). The majority (91%) of participants with hs‐ cTnT levels of 5‐14 ng/L had a negative EST as well as 89.3% of subjects with levels >14 ng/L. The proportion of subjects with a positive EST and detectable hs‐ cTnT levels (>5 ng/L) was not significantly greater compared to those with a negative EST (53.1% vs 46.2%, respectively, P = .09). Conclusion Among subjects referred for EST as part of an annual health survey, we found no significant association between EST results to hs‐ cTnT detection.