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Mechanisms and disease relevance of neutrophil extracellular trap formation
Author(s) -
Van Avondt Kristof,
Hartl Dominik
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12919
Subject(s) - neutrophil extracellular traps , relevance (law) , disease , extracellular , mechanism (biology) , neuroscience , clinical significance , biology , medicine , immunology , microbiology and biotechnology , inflammation , epistemology , pathology , philosophy , political science , law
While the microscopic appearance of neutrophil extracellular traps (NETs) has fascinated basic researchers since its discovery, the (patho)physiological mechanisms triggering NET release, the disease relevance and clinical translatability of this unconventional cellular mechanism remained poorly understood. Here, we summarize and discuss current concepts of the mechanisms and disease relevance of NET formation.