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Association of oxidative stress with clinical characteristics in patients with rheumatoid arthritis
Author(s) -
Kardeş Sinan,
Karagülle Mine,
Durak İlker,
Avcı Aslıhan,
Karagülle Müfit Z.
Publication year - 2018
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12858
Subject(s) - medicine , rheumatoid arthritis , oxidative stress , malondialdehyde , biomarker , superoxide dismutase , post hoc analysis , gastroenterology , biochemistry , biology
Background Few studies examining the association between oxidative stress and clinical parameters or disease activity in patients with rheumatoid arthritis ( RA ) are available. Therefore, the objective of this study was to test whether oxidative stress has any association with clinical parameters and disease activity in patients with RA . Materials and methods In this post hoc cross‐sectional study, 45 patients with RA treated with traditional disease‐modifying antirheumatic drugs ( DMARD s) ± low‐dose glucocorticoids ± nonsteroidal analgesics for at least 3 months were analysed. Oxidative stress parameters were malondialdehyde ( MDA ), superoxide dismutase ( SOD ), antioxidant potential ( AOP ) and nonenzymatic superoxide radical scavenger activity ( NSSA ). Clinical parameters were pain, patient global assessment, physician global assessment, Health Assessment Questionnaire ( HAQ ), and disease activity score ( DAS 28). Results Plasma NSSA levels were significantly inversely correlated with tender joints count ( r = −.304; P = .042), swollen joints count ( r = −.342; P = .021) and DAS 28 ( r = −.396; P = .009). There were no significant correlations between MDA / SOD / AOP and any of clinical parameters or DAS 28 ( P > .05 for all). Multiple regression analysis revealed that NSSA was an independent variable of DAS 28 (β=−.243, P = .016). Conclusion The preliminary results demonstrate that plasma NSSA levels were inversely correlated with tender and swollen joints count and DAS 28 and that NSSA was independently associated with DAS 28, in patients with RA treated with traditional DMARD s; and provide initial support that NSSA may be used as a biomarker of disease activity in patients with RA .