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The association of profilin‐1 levels with survival in chronic kidney disease
Author(s) -
Eroglu Eray,
Unal Hilmi U.,
Guclu Aydin,
Kocyigit Ismail,
Karaman Murat,
Saglam Mutlu,
Gezer Mustafa,
Tas Ahmet,
Zararsiz Gokmen,
Eyileten Tayfun,
Aydin İbrahim,
Oguz Yusuf,
Gungor Ozkan,
Yilmaz Mahmut I.
Publication year - 2017
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12839
Subject(s) - profilin , actin , medicine , brachial artery , vasodilation , endothelium , cohort , actin cytoskeleton , cardiology , endocrinology , cytoskeleton , biology , microbiology and biotechnology , blood pressure , biochemistry , cell
Background Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1‐5 CKD . Materials and methods Serum concentrations of profilin‐1 levels were determined by enzyme‐linked immunosorbent assay. Endothelium‐dependent vasodilatation (flow‐mediated dilatation [ FMD ]) and endothelium‐independent vasodilatation (nitroglycerine‐mediated dilatation [ NMD ]) of the brachial artery were assessed noninvasively, using high‐resolution ultrasound. Results Both fatal and nonfatal CVE were significantly higher in patients with high profilin‐1 levels. Kaplan‐Meier survival curves showed that patients with profilin‐1 below the median value (114 pg/mL) had higher cumulative survival compared with patients who had profilin‐1 levels above the median value (log‐rank test, P < .001). Conclusions This is the first study that demonstrates the serum profilin‐1 is independently associated with endothelial dysfunction, cardiovascular events and survival in patients with CKD .