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Adipose tissue content of saturated fatty acids and atrial fibrillation: A case‐cohort study
Author(s) -
Dinesen Pia T.,
Rix Thomas A.,
Joensen Albert M.,
Tjønneland Anne,
LundbyeChristensen Søren,
Overvad Kim,
Schmidt Erik B.
Publication year - 2017
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12836
Subject(s) - adipose tissue , atrial fibrillation , medicine , palmitic acid , cohort , stearic acid , myristic acid , fatty acid , saturated fatty acid , cohort study , proportional hazards model , gastroenterology , cardiology , chemistry , biochemistry , organic chemistry
Objectives The aim of this study was to investigate the association between adipose tissue content of total saturated fatty acids including myristic (C14:0), palmitic (C16:0) and stearic (C18:0) acid, as a measure of exposure to saturated fatty acids and the risk of incident atrial fibrillation. Materials and methods A total of 57 053 Danish men and women aged 50‐64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline, and this was analysed for saturated fatty acids content by gas chromatography. Follow‐up was registry based and in this case‐cohort study we used all cases and a randomly drawn subcohort of 3500 participants representative for the entire cohort. Results Data were analysed using weighted Cox proportional hazards regression. During a median follow‐up of 14.6 years, a total of 4722 cases of incident atrial fibrillation were diagnosed. For both men and women, no association between adipose tissue content of total saturated fatty acids and the risk of atrial fibrillation could be demonstrated. Conclusion We did not find an association between adipose tissue content of total saturated fatty acids and the risk of incident atrial fibrillation.