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Vitamin D predictors in polycystic ovary syndrome: a meta‐analysis
Author(s) -
Bacopoulou Flora,
Kolias Evangelia,
Efthymiou Vasiliki,
Antonopoulos Constantine N.,
Charmandari Evangelia
Publication year - 2017
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12800
Subject(s) - polycystic ovary , medicine , endocrinology , sex hormone binding globulin , vitamin d and neurology , body mass index , insulin resistance , free androgen index , testosterone (patch) , insulin , hormone , androgen
Background The aim of this meta‐analysis was to examine differences and predictors of serum 25‐hydroxyvitamin D concentrations in women with polycystic ovary syndrome ( PCOS ) compared with non‐ PCOS controls matched for body mass index. Materials and methods Three databases were searched (2003–2015) to retrieve studies that evaluated serum 25‐hydroxyvitamin D in PCOS women and controls. Meta‐regression analysis was performed with anthropometric and metabolic/endocrine parameters as covariates. Results Fourteen studies that included 2262 women (1150 PCOS patients/1162 controls) were eligible. Serum 25‐hydroxyvitamin D, follicle‐stimulating hormone and sex hormone‐binding globulin were significantly lower in patients with PCOS than controls. Homoeostatic model assessment‐insulin resistance index, serum insulin, total cholesterol, triglycerides, low‐density lipoprotein cholesterol, luteinising hormone and testosterone were significantly higher in patients with PCOS compared to controls. Meta‐regression analysis demonstrated significant effects of waist‐to‐hip ratio and glucose in PCOS women (β = −1·60, 95% CI : −2·30 to −0·90, P = 0·003; β = 0·20, 95% CI : 0·80–0·32, P = 0·004, respectively) and controls (β = −2·36, 95% CI : −3·38 to −1·33, P = 0·003; β = 0·11, 95% CI : 0·00–0·21, P = 0·05, respectively) and of total calcium and luteinising hormone in PCOS cases (β = 2·43, 95% CI : 1·67–3·19, P = 0·005; β = −0·37, 95% CI : −0·68 to −0·06, P = 0·03, respectively). Conclusions Serum 25‐hydroxyvitamin D may be predicted positively by serum calcium and negatively by luteinising hormone in women with PCOS , and negatively by waist‐to‐hip ratio and positively by fasting glucose in both PCOS and non‐ PCOS women, independently of the presence of obesity.