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The relationship of serum adipokines with malnutrition inflammation score in haemodialysis
Author(s) -
Alipoor Elham,
Esmaillzadeh Ahmad,
MahdaviMazdeh Mitra,
Yaseri Mehdi,
Zahed Narges Sadat,
HosseinzadehAttar Mohammad Javad
Publication year - 2017
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12774
Subject(s) - adipose triglyceride lipase , medicine , endocrinology , wasting , adipokine , lipolysis , triglyceride , chemistry , transferrin , adipose tissue , leptin , obesity , cholesterol
Abstract Background Protein–energy wasting is a prevalent disorder in haemodialysis. Zinc‐α2‐glycoprotein ( ZAG ) and adipose triglyceride lipase ( ATGL ) are novel adipokines with recognized lipolytic effects and proposed role in metabolic homoeostasis. This study was conducted to investigate the association of ZAG and ATGL concentrations with malnutrition–inflammation score ( MIS ) and metabolic profile of patients with haemodialysis. Materials and methods Eighty‐eight patients under regular haemodialysis were divided based on MIS to normal to mild wasting ( NMW ; n = 35) or moderate wasting ( MW ; n = 53) group. Anthropometric measurements along with fasting serum concentrations of ZAG , ATGL , free fatty acids ( FFA s), albumin, transferrin, total iron‐binding capacity ( TIBC ), hs‐ CRP , lipid profile and glucose metabolism were assessed. Results Adipose triglyceride lipase concentration was significantly higher in MW than NMW group (10·89 ± 5·7 vs. 8·02 ± 3·37 mIU / mL ; P = 0·008). The ZAG and FFA s were not significantly different between two groups. ATGL was directly correlated with FFA s in all of the patients ( r = 0·284, P = 0·007) and MW ( r = 0·32, P = 0·021), and marginally in NMW ( r = 0·31, P = 0·057) groups. ATGL and odds of having mild or moderate wasting were significantly correlated (OR = 1·21, P = 0·033). A positive association was observed between ATGL with TG ( r = 0·31, P = 0·049) and also with transferrin and TIBC ( r = 0·44, P = 0·001) only in MW group. An inverse relationship was observed between ATGL and HDL in all of the participants ( r =−0·222, P = 0·04). No significant correlation was observed between ZAG and other parameters. Conclusions The serum concentrations of ATGL , but not ZAG , were significantly higher in MW compared to NMW group. Each unit increase in ATGL concentrations was correlated with 21% increase in the odds of wasting severity. ATGL might play a role in wasting pathogenesis and metabolic profile in haemodialysis.