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Smoking and obesity in systemic lupus erythematosus: a cross‐sectional study
Author(s) -
Versini Mathilde,
Tiosano Shmuel,
Comaneshter Doron,
Shoenfeld Yehuda,
Cohen Ar D.,
Amital Howard
Publication year - 2017
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12757
Subject(s) - medicine , body mass index , obesity , logistic regression , multivariate analysis , cross sectional study , socioeconomic status , lupus erythematosus , univariate analysis , environmental health , multivariate statistics , immunology , population , pathology , antibody , statistics , mathematics
Abstract Background Both smoking and obesity have been demonstrated as risk factors in several autoimmune diseases. Little is known about the relationship between systemic lupus erythematosus ( SLE ) and both smoking and obesity. Objectives To investigate the association between SLE , tobacco consumption and body mass index ( BMI ). Materials and methods Using data from the largest Health Maintenance Organization ( HMO ) in Israel, the Clalit Health Services, we searched for an association between SLE , smoking and obesity. Chi‐square and t ‐test were used for univariate analysis, and a logistic regression model was used for multivariate analysis. Data available from Clalit Health Services database included age, sex, BMI , smoking status, socioeconomic status ( SES ) and diagnoses of chronic diseases. Results The study included 5018 patients with SLE and 25 090 age‐ and sex‐matched controls. In multivariate analysis, we found a significant association between smoking and SLE ( OR = 1·91). Conversely, there was no association between BMI and SLE . Conclusion In this study, we have shown that smoking is independently associated with SLE , whereas BMI scores were not.