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IL‐1B rs16944 polymorphism is related to septic shock and death
Author(s) -
JiménezSousa María Ángeles,
Medrano Luz M.,
Liu Pilar,
Almansa Raquel,
FernándezRodríguez Amanda,
GómezSánchez Esther,
Rico Lucía,
HerediaRodríguez María,
GómezPesquera Estefanía,
Tamayo Eduardo,
Resino Salvador
Publication year - 2017
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12702
Subject(s) - septic shock , biology , genetics , polymorphism (computer science) , medicine , sepsis , immunology , gene , genotype
Background IL ‐1β is a primary mediator of systemic inflammatory response syndrome ( SIRS ) and it may lead to shock septic. Our aim was to analyse whether IL ‐1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. Materials and methods We performed a case–control study on 467 patients who underwent major cardiac or abdominal surgery. Of them, 205 patients developed septic shock (cases, SS group) and 262 patients developed SIRS (controls, SIRS group). The primary outcome variables were the development of septic shock and death within 90 days after diagnosis of septic shock. The IL ‐1B rs16944 polymorphism was genotyped by Sequenom's Mass ARRAY platform. The association analysis was performed under a recessive genetic model ( AA vs. GG / GC ). Results The frequency of septic shock was higher in patients with IL ‐1B rs16944 AA genotype than in patients with IL ‐1B rs16944 GG / AG genotype when all patients were taken into account (63·6% vs. 41·8%; P = 0·006), cardiac surgery (52·2% vs. 33·3%; P = 0·072) and abdominal surgery (76·2% vs. 50·2%; P = 0·023). However, the IL ‐1B rs16944 AA genotype was only associated with higher likelihood of septic shock in the analysis of all population [adjusted odds ratio ( aOR ) = 2·26 (95% CI = 1·03; 4·97; P = 0·042], but not when it was stratified by cardiac surgery ( P = 0·175) or abdominal surgery ( P = 0·467). Similarly, IL ‐1B rs16944 AA genotype was also associated with higher likelihood of septic shock‐related death in all population [ aOR = 2·67 (95% CI = 1·07; 4·97); P = 0·035]. Conclusions IL ‐1B rs16944 AA genotype seems to be related to the onset of septic shock and death in patients who underwent major surgery.