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Triglyceride‐rich lipoprotein metabolism in women: roles of apoC‐ II and apoC‐ III
Author(s) -
Ooi Esther M.,
Chan Dick C.,
Hodson Leanne,
Adiels Martin,
Boren Jan,
Karpe Fredrik,
Fielding Barbara A.,
Watts Gerald F.,
Barrett P. Hugh R.
Publication year - 2016
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12657
Subject(s) - very low density lipoprotein , triglyceride , apolipoprotein b , medicine , endocrinology , chemistry , lipoprotein , cholesterol , biology
Background Experimental data suggest that apolipoprotein (apo) C‐ II and C‐ III regulate triglyceride‐rich lipoprotein ( TRL ) metabolism, but there are limited studies in humans. We investigated the metabolic associations of TRL s with apoC‐ II and apoC‐ III concentrations and kinetics in women. Material and methods The kinetics of plasma apoC‐ II , apoC‐ III and very low‐density lipoprotein ( VLDL ) apoB‐100 and triglycerides were measured in the postabsorptive state using stable isotopic techniques and compartmental modelling in 60 women with wide‐ranging body mass index (19·5–32·9 kg/m 2 ). Results Plasma apoC‐ II and apoC‐ III concentrations were positively associated with the concentrations of plasma triglycerides, VLDL 1 ‐ and VLDL 2 ‐apoB‐100 and triglyceride (all P < 0·05). ApoC‐ II production rate ( PR ) was positively associated with VLDL 1 ‐apoB‐100 concentration, VLDL 1 triglyceride concentration and VLDL 1 triglyceride PR , while apoC‐ II fractional catabolic rate ( FCR ) was positively associated with VLDL 1 triglyceride FCR (all P < 0·05). No significant associations were observed between apoC‐ II and VLDL 2 apoB‐100 or triglyceride kinetics. ApoC‐ III PR , but not FCR , was positively associated with VLDL 1 triglyceride, and VLDL 2 ‐apoB‐100 and triglyceride concentrations (all P < 0·05). No significant associations were observed between apoC‐ III and VLDL ‐apoB‐100 and triglyceride kinetics. In multivariable analysis, including homoeostasis model assessment score, menopausal status and obesity, apoC‐ II concentration was significantly associated with plasma triglyceride, VLDL 1 ‐apoB‐100 and VLDL 1 triglyceride concentrations and PR . Using the same multivariable analysis, apoC‐ III was significantly associated with plasma triglyceride and VLDL 1 ‐ and VLDL 2 ‐apoB‐100 and triglyceride concentrations and FCR . Conclusions In women, plasma apoC‐ II and apoC‐ III concentrations are regulated by their respective PR and are significant, independent determinants of the kinetics and plasma concentrations of TRL s.