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Increased thioredoxin levels are related to insulin resistance in familial combined hyperlipidaemia
Author(s) -
MartinezHervas Sergio,
Artero Ana,
MartinezIbañez Juncal,
Tormos Mari C.,
GonzalezNavarro Herminia,
Priego Antonia,
MartinezValls Jose F.,
Saez Guillermo T.,
Real Jose T.,
Carmena Rafael,
Ascaso Juan F.
Publication year - 2016
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12642
Subject(s) - oxidative stress , medicine , glutathione , insulin resistance , endocrinology , thioredoxin , inflammation , insulin , chemistry , biochemistry , enzyme
Background Thioredoxins ( TRX ) are major cellular protein disulphide reductases that are critical for redox regulation. Oxidative stress and inflammation play promoting roles in the genesis and progression of atherosclerosis, but until now scarce data are available considering the influence of TRX activity in familial combined hyperlipidaemia ( FCH ). Since FCH is associated with high risk of cardiovascular disease, the objective of the present study was to assess oxidative stress status in FCH patients, and evaluate the influence of insulin resistance ( IR ). Materials and methods A cohort of 35 control subjects and 35 non‐related FCH patients were included, all of them nondiabetic, normotensive and nonsmokers. We measured lipid profile, glucose and insulin levels in plasma, and markers of oxidative stress and inflammation such as oxidized glutathione ( GSSG ), reduced glutathione ( GSH ) and TRX . Results Familial combined hyperlipidaemia subjects showed significantly higher levels of GSSG , GSSG / GSH ratio and TRX than controls. In addition, FCH individuals with IR showed the worst profile of oxidative stress status compared to controls and FCH patients without IR ( P < 0·01). TRX levels correlated with higher insulin resistance. Conclusion Familial combined hyperlipidaemia patients showed increased TRX levels. TRX was positively correlated with IR . These data could partially explain the increased risk of cardiovascular events in primary dyslipidemic patients.