Premium
Heart acceleration and deceleration capacities associated with dilated cardiomyopathy
Author(s) -
Zou Cao,
Dong Hongkai,
Wang Fengyan,
Gao Meiwen,
Huang Xingmei,
Jin Jianling,
Zhou Bingyuan,
Yang Xiangjun
Publication year - 2016
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12594
Subject(s) - cardiology , dilated cardiomyopathy , medicine , heart rate , logistic regression , heart failure , ejection fraction , acceleration , odds ratio , cardiomyopathy , confidence interval , blood pressure , physics , classical mechanics
Abstract Background Heart rate deceleration capacity and acceleration capacity are novel autonomic nervous system indicators of cardiac neural regulation. Dilated cardiomyopathy ( DCM ) changes cardiac electrophysiology; however, how deceleration capacity and acceleration capacity associated with DCM remain unclear. Materials and methods To evaluate the association between heart rate acceleration capacity, deceleration capacity and DCM , 66 DCM patients with DCM and 209 controls were enrolled in the study. Demographic data, echocardiographic data, heart rate variability, deceleration capacity and acceleration capacity were collected. The association pattern between DCM and these indexes were studied by multiple logistic regression analysis. Results Deceleration capacity and acceleration capacity were independent risk factors for DCM with an odds ratio ( OR ) and 95% confidence interval ( CI ), determined by multiple logistic regression analysis, of 7·97 (3·87–16·42) and 0·09 (0·05–0·19), respectively. Univariate ordinal logistic regression analysis showed that acceleration capacity, fastest heart rate, standard deviation of normal‐to‐normal RR intervals ( SDNN ) and left ventricular ejection fraction ( LEVF ) associated with heart failure grade. The OR for each covariate was further adjusted for the effects of other significant covariates in multivariate ordinal logistic regression analysis. Acceleration capacity, fastest heart rate and LVEF were still independent risk factors in the final equation with OR s of 1·32 (1·03–1·79), 1·04 (0·01–1·07) and 0·46 (0·23–0·93), respectively. Conclusion Heart rate acceleration capacity and deceleration capacity are independent risk factors for DCM , and acceleration capacity is a predictive factor for heart failure exacerbation in patients with DCM .