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Immune dysregulation in the functional gastrointestinal disorders
Author(s) -
Keely Simon,
Walker Marjorie M.,
Marks Ellen,
Talley Nicholas J.
Publication year - 2015
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12548
Subject(s) - irritable bowel syndrome , immune dysregulation , disease , immune system , functional gastrointestinal disorder , medicine , mechanism (biology) , immunology , gastroenterology , philosophy , epistemology
Abstract Gastrointestinal conditions may be broadly classified into two: organic and functional disease, with functional disorders accounting for the majority of patients with chronic gastrointestinal symptoms. Functional gastrointestinal disorders ( FGID s) present with no obvious pathology or well‐accepted biochemical mechanism and, as such, treatment strategies are limited and focus on symptoms rather than cure. Irritable bowel syndrome and functional dyspepsia are the most widely recognised FGID s, and there is a growing body of evidence to suggest an underlying inflammatory phenotype in subsets with these conditions. Here, we discuss the current knowledge of immune involvement in FGID s and the commonalities between the different manifestations of FGID s and propose a new hypothesis, potentially defining an underlying immunopathological basis of these conditions.