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Lipid parameters in patients with acute coronary syndromes versus stable coronary artery disease
Author(s) -
Vonbank Alexander,
Saely Christoph H.,
Rein Philipp,
Drexel Heinz
Publication year - 2015
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12513
Subject(s) - cardiology , medicine , coronary artery disease , acute coronary syndrome , coronary disease , myocardial infarction , coronary heart disease
Background Differences in lipid parameters between patients with acute coronary syndromes ( ACS ) and patients with stable coronary artery disease ( CAD ) are unclear and are addressed in this study. Methods We enrolled 582 patients with angiographically proven stable CAD (of whom 26·9% had diabetes mellitus type 2 (T2 DM )) and 182 patients with ACS (of whom 35·8% had T2 DM ). Results HDL cholesterol and apolipoprotein A1 levels were significantly lower in patients with ACS than in patients with CAD (46 ± 16 mg/dL vs. 50 ± 16 mg/dL, P < 0·001, and 139 ± 30 mg/dL vs. 155 ± 31 mg/dL, P < 0·001, respectively). Analysis of covariance ( ancova ) adjusting for age, gender, smoking, BMI , statin therapy, alcohol use, hypertension and diabetic state confirmed an independent impact of ACS on HDL cholesterol and apolipoprotein A1 levels ( F = 24·1; P < 0·001). In contrast, total cholesterol, LDL cholesterol, non‐ HDL cholesterol and apolipoprotein B levels did not differ significantly between patients with ACS and patients with stable CAD . Conclusion HDL cholesterol and apolipoprotein A1 levels are lower in patients with ACS than in patients with stable CAD .