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Phosphorylcholine antibodies are diminished in ANCA ‐associated vasculitis
Author(s) -
Wilde Benjamin,
Slot Marjan,
Paassen Pieter,
Theunissen Ruud,
Kemna Michael,
Witzke Oliver,
Cohen Tervaert Jan Willem
Publication year - 2015
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12457
Subject(s) - phosphorylcholine , antibody , vasculitis , medicine , immunology , autoantibody , pathology , disease , biology , biochemistry
Abstract Background/Aim ANCA ‐associated ( AAV ) vasculitis is an autoimmune small‐vessel vasculitis and may be associated with accelerated atherosclerosis as suggested by current literature. Antibodies against oxidized lipoproteins (Ox LDL ) and phosphorylcholine (Pc) protect from atherosclerosis. This study characterizes these antibodies in AAV . Methods Pc‐ and anti‐Ox LDL antibodies were determined in sera of 39 AAV patients and 44 healthy controls ( HC ). Intima‐media thickness ( IMT , carotids) and pulse wave velocity ( PWV , A. femoralis) were measured. Results Pc‐/Ox LDL IgM antibodies were significantly reduced in AAV . IMT and PWV were negatively associated with anti‐Pc antibodies in HC only. Conclusion Atheroprotective anti‐Pc/anti‐Ox LDL antibodies are significantly reduced in AAV possibly explaining accelerated atherosclerosis in vasculitis patients.