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Serum osteopontin levels are upregulated and predict disability after an ischaemic stroke
Author(s) -
Carbone Federico,
Vuilleumier Nicolas,
Burger Fabienne,
Roversi Gloria,
Tamborino Carmine,
Casetta Ilaria,
Seraceni Silva,
Trentini Alessandro,
Padroni Marina,
Dallegri Franco,
Mach François,
Fainardi Enrico,
Montecucco Fabrizio
Publication year - 2015
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12446
Subject(s) - medicine , osteoprotegerin , osteopontin , modified rankin scale , rankl , receiver operating characteristic , gastroenterology , stroke (engine) , cohort , receptor , ischemic stroke , ischemia , activator (genetics) , mechanical engineering , engineering
Background After an acute ischaemic stroke ( AIS ), several inflammatory biomarkers have been investigated, but their predictive role on functional recovery remains to be validated. Here, we investigated the prognostic relevance of biomarkers related to atherosclerotic plaque calcification, such as osteopontin ( OPN ), osteoprotegerin ( OPG ) and the receptor activator of nuclear factor kappa‐B ligand ( RANKL ) in a cohort of patients with AIS ( n = 90) during 90‐day follow‐up. Materials and methods Radiological and clinical examinations as well as blood sampling were performed at admission and at days 1, 7 and 90 from the event. Validated scores [such as modified Rankin scale ( mRS ) and the National Institutes of Health Stroke Scale ( NIHSS )] were used to assess poststroke outcome. Serum levels of OPN , OPG and RANKL were measured by colorimetric enzyme‐linked immunosorbent assay ( ELISA ). Results When compared to the admission, OPN serum levels increased at day 7. Serum OPN levels at this time point were positively correlated with both ischaemic lesion volume and NIHSS at days 7 and 90. A cut‐off of 30·53 ng/mL was identified for serum OPN by receiver operating characteristic (ROC) curve analysis. Adjusted logistic regression showed that serum OPN levels at day 7 predicted worse mRS at day 90 [ OR 4·13 (95% CI 1·64–10·36); P = 0·002] and NIHSS [1·49 (95% CI 1·16–1·99); P = 0·007], independently of age, gender, hypertension and thrombolysis. Conclusions Serum levels of OPN , but not OPG and RANKL , peaked at day 7 after AIS and predicted worse neurological scores. Therefore, OPN might have a pathophysiological and clinical relevance after AIS .