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The interplay between p66Shc, reactive oxygen species and cancer cell metabolism
Author(s) -
LebiedzinskaArciszewska Magdalena,
Oparka Monika,
VegaNaredo Ignacio,
KarkucinskaWieckowska Agnieszka,
Pinton Paolo,
Duszynski Jerzy,
Wieckowski Mariusz R.
Publication year - 2015
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12364
Subject(s) - metastasis , prostate cancer , cell growth , cancer , cancer research , biology , lncap , intracellular , oxidative stress , microbiology and biotechnology , receptor , cancer cell , medicine , endocrinology , biochemistry
The adaptor protein p66Shc links membrane receptors to intracellular signalling pathways and has the potential to respond to energy status changes and regulate mitogenic signalling. Initially reported to mediate growth signals in normal and cancer cells, p66Shc has also been recognized as a pro‐apoptotic protein involved in the cellular response to oxidative stress. Moreover, it is a key element in processes such as cancer cell proliferation, tumor progression, metastasis and metabolic reprogramming. Recent findings on the role of p66Shc in the above‐mentioned processes have been obtained through the use of various tumor cell types, including prostate, breast, ovarian, lung, colon, skin and thyroid cancer cells. Interestingly, the impact of p66Shc on the proliferation rate was mainly observed in prostate tumors, while its impact on metastasis was mainly found in breast cancers. In this review, we summarize the current knowledge about the possible roles of p66Shc in different cancers.