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Nocturnal stem cell mobilization in patients with obstructive sleep apnoea: a pilot study
Author(s) -
Chou KunTa,
Liu ChenChi,
Hsu HanShui,
Chang ShiChuan,
Chen YuhMin,
Perng DiahnWarng,
Hsu YuanTong,
Lee YuChin,
Hung ShihChieh
Publication year - 2014
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12353
Subject(s) - medicine , polysomnography , body mass index , mobilization , stem cell , morning , cardiology , anesthesia , surgery , apnea , genetics , archaeology , biology , history
Background Patients with obstructive sleep apnoea ( OSA ) experience repetitive cessation of breathing during sleep, leading to intermittent hypoxaemia, excessive oxidative stress and systemic inflammation. These insults may damage the vasculature and provoke the corresponding repair response, such as stem cell mobilization to peripheral blood. This study aimed to investigate nocturnal mobilization of stem cells in OSA . Methods Thirty‐five patients with OSA and thirteen healthy controls were enrolled. Polysomnography was performed, and severity of OSA was defined by apnoea–hypopnoea index ( AHI ). Peripheral venous blood was drawn after and before sleep for measurement of CD 34+ cell and SDF ‐1α level. Stem cell mobilization was gauged by ratios of the CD 34+ level in the morning to that at night or by their difference. Correlation analysis was performed to identify factors related to stem cell mobilization. Results Compared to controls, the nocturnal ratios and difference of CD 34+ cell levels were larger in patients with OSA (ratios: 1·141 vs. 0·896, P = 0·036; difference: 340 vs. −166/cc blood, P = 0·036), suggestive of stem cell mobilization. The mobilization ratios were related to AHI , body mass index ( BMI ), SpO2 nadir, oxygen desaturation index and time sustaining hypoxaemia. After adjusting age, gender and BMI , AHI ( r = 0·357, P = 0·016) and hypoxaemia‐related parameter remained significant. Paired nocturnal differences in CD 34+ cell count ( P = 0·009) and SDF ‐1α ( P = 0·001) were also significant in patients with OSA , but not in controls. After CPAP therapy for 6 months, the elevated mobilization ratios in patients with OSA tended to decline ( P = 0·059). Conclusion CD 34+ stem cell mobilization during sleep was observed in OSA .