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Advanced oxidation protein products and ischaemia‐modified albumin in obstructive sleep apnea
Author(s) -
Ozben Serkan,
Huseyinoglu Nergiz,
Hanikoglu Ferhat,
Guvenc Tolga Sinan,
Yildirim Binnaz Zeynep,
Cort Aysegul,
Ozdem Sebahat,
Ozben Tomris
Publication year - 2014
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12338
Subject(s) - obstructive sleep apnea , oxidative stress , medicine , albumin , sleep apnea , polysomnography , serum albumin , protein carbonylation , apnea , gastroenterology , lipid peroxidation
Background Several studies have shown that obstructive sleep apnea increases incidence of cardiovascular morbidity and mortality. The high systemic oxidative stress in obstructive sleep apnea has been considered as a major pathogenic mechanism leading to cardiovascular disease. Oxidative stress‐related lipid and DNA oxidation in obstructive sleep apnea have been reported in the previous studies. In contrast, there is limited and contradictory information regarding protein oxidation in obstructive sleep apnea patients such as ischaemia‐modified albumin and advanced oxidation protein products. Therefore, we aimed to investigate plasma ischaemia‐modified albumin and advanced oxidation protein products and their correlation with total oxidative status and total antioxidative capacity in the obstructive sleep apnea patients. Methods Plasma ischaemia‐modified albumin, advanced oxidation protein products, total oxidative status and total antioxidative capacity were measured in 25 healthy volunteers and 59 obstructive sleep apnea patients diagnosed with polysomnography. Results Plasma total antioxidative capacity was significantly lower ( P = 0·012) and total oxidative status was significantly higher ( P < 0·001) in the patients compared to the controls demonstrating increased oxidative stress in the patients. Plasma advanced oxidation protein products were significantly higher in the patients than the controls ( P = 0·024). Plasma ischaemia‐modified albumin levels were not statistically different between the obstructive sleep apnea patients and controls ( P = 0·74). Conclusions We conclude that high systemic oxidative stress in obstructive sleep apnea is reflected by increased advanced oxidation protein products without causing an increase in ischaemia‐modified albumin.